A One-pot Synthesis of Nitrohydroxylated Pyrrolidine and Piperidine Ring Sytems by Tandem Michael-Henry Reaction

Article abstract of DOI:10.1016/0040-4039(94)88491-9

Nitrohydroxylated pyrrolidine and piperidine ring systems are coveniently obtained through a one-pot procedure involving sequential Michael-Henry reaction between nitroethylene and a nitrogen nucleophile incorporating a suitably placed precursor for the generation either reductively or oxidatively of an aldehyde group which is directly trapped in the subsequent nitroaldolization step.