Tetrahedron Letters p. 9293 - 9296 (1994)
Update date:2022-08-16
Topics:
Barco, Achille
Benetti, Simonetta
Risi, Carmela De
Pollini, Gian P.
Romagnoli, Romeo
Zanirato, Vinicio
Nitrohydroxylated pyrrolidine and piperidine ring systems are coveniently obtained through a one-pot procedure involving sequential Michael-Henry reaction between nitroethylene and a nitrogen nucleophile incorporating a suitably placed precursor for the generation either reductively or oxidatively of an aldehyde group which is directly trapped in the subsequent nitroaldolization step.
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