Selective O-benzylation of aminoalkanols

Article abstract of DOI:10.1080/00397919508013428

A simple and one-step method has been developed for selective O-benzylation of aminoalkanols. Study of steric effects shows the best selectivity in adjacent 1°-OH vs 2°-CHNH₂ and decreased selectivity in 2°-OH vs 1°-CH₂NH₂ and non adjacent aminoalkanol.

Full text of DOI:10.1080/00397919508013428

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Synthetic Communications: An
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Communication of Synthetic
Organic Chemistry
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Selective O-Benzylation of
Aminoalkanols
a b
a
X. Eric Hu
& John M. Cassady
a
Department of Medicinal Chemistry and
Pharmacognosy College of Pharmacy, The Ohio State
University, Columbus, OH, 43210
b
Procter & Gamble Pharmaceuticals, Miami Valley
Laboratories, P.O. Box 398707, Cincinnati, OH,
45239-8707
Version of record first published: 23 Sep 2006.
To cite this article: X. Eric Hu & John M. Cassady (1995): Selective O-Benzylation
of Aminoalkanols, Synthetic Communications: An International Journal for Rapid
Communication of Synthetic Organic Chemistry, 25:6, 907-913
To link to this article: http://dx.doi.org/10.1080/00397919508013428
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