Hydroxycarbonylation of Aryl Halides with Formate Salts Catalyzed by Palladium Complexes

Article abstract of DOI:10.1021/jo00238a027

Substituted aryl halides were hydroxycarbonylated under 50 psi pressure of carbon monoxide in the presence of various formate salts and a homogeneous palladium catalyst to give aromatic acids in good yields.Selectivity of formate salts in hydroxycarbonylation reactions depends on the metallic counter-ion and the reaction conditions.Calcium formate was found to give the highest selectivity for hydroxycarbonylation.A mechanism consisting of the generation of mixed anhydrides as intermediates is suggested.