Synlett p. 2237 - 2239 (2003)
Update date:2022-08-25
Topics:
Ramnauth, Jailall
Bhardwaj, Namrta
Renton, Paul
Rakhit, Suman
Maddaford, Shawn P.
The palladium-catalyzed cyanation of aryl bromides and iodides to the corresponding nitriles occurs at room temperature when tri-t-butylphosphine is used as ligand, Zn(CN)2 as the cyanide source and Zn dust as a co-catalyst in DMF as solvent. A variety of aromatic halides, including electron-withdrawing and electron-donating, can be efficiently cyanated under these conditions. The reactions are completed in less than 1 hour and products are produced in good to excellent yield.
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