Synthesis of Methyl (Z)-2-Acetamido-3-aryl-2-butenoates in Two Highly Selective Steps

DOI: 10.1055/s-1986-31660

Source and publish data:

Synthesis p. 418 - 419 (1986)

Update date:2022-08-22

Topics:

Authors:

Cativiela, C.

Diaz de Villegas, M. D.

Melendez, E.

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Article abstract of DOI:10.1055/s-1986-31660

Diazomethane reacts with methyl (Z)-2-acetamido-3-aryl-2-propenoates regio- and stereospecifically to afford cis-4-aryl-3-acetamido-3-methoxycarbonyl-Δ¹-pyrazolines which heated in 1,2-ethanediol at 200 deg C extrude nitrogen to afford stereospecifically methyl (Z)-2-acetamido-3-aryl-2-butenoates in high yields.

Full text of DOI:10.1055/s-1986-31660

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Product name:2-Butenoic acid, 2-(acetylamino)-3-(4-methylphenyl)-, methyl ester, (Z)-

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