Zinc mediated addition of active halides to a glycine cation equivalent: Synthesis of N-Boc-L-propargylglycine

Article abstract of DOI:10.1016/S0040-4039(00)73067-X

The reaction of allylic, benzylic and propargylic halides with zine in the presence of the glycine cation equivalent, methyl N-Boc-2-acetoxyglycine, affords Boc protected amino acid derivatives in high yield. Resolution of methyl N-Boc- propargylglycine w