A new regio-defined synthesis of PMEA

Article abstract of DOI:10.1080/07328319808003479

A new regio-defined synthesis of PMEA was developed suitable for gramscale synthesis. Key to this synthesis was the early introduction of the phosphonomethoxy ethyl moiety and subsequent cyclization for the construction of the purine ring. This synthesis is regiospecific when compared to the commonly used adenine alkylation methods.

Full text of DOI:10.1080/07328319808003479

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Nucleosides and Nucleotides
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A New Regio-Defined Synthesis of PMEA
Qun Dang a , Van Liu a & Mark D. Erion a
a Department of Medicinal Chemistry Metabasis Therapeutics , Inc.
9360 Towne Centre Drive, San Diego, CA, 92121
Published online: 21 Aug 2006.
To cite this article: Qun Dang , Van Liu & Mark D. Erion (1998) A New Regio-Defined Synthesis of
PMEA, Nucleosides and Nucleotides, 17:8, 1445-1451, DOI: 10.1080/07328319808003479
To link to this article: http://dx.doi.org/10.1080/07328319808003479
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