The synthesis of highly reactive, multi-functional α,β-epoxy- and α-acetoxy-nitrosamines

Article abstract of DOI:10.1016/S0040-4039(97)10868-1

The synthesis of the reactive acetates, trans-3-acetoxy-2-hydroxy-N-nitrosomorpholine 3 and N-(1-acetoxy-2-hydroxyethyl)-N-nitrosoethanolamine 12, of two α-hydroxynitrosamines has been accomplished through the ring opening of the corresponding epoxides, NEMOR and 10 which were prepared by dimethyldioxirane oxidation of the vinyl nitrosamines.