Prediction of the Optimum Reaction Time for Carbon-11 Labelling Reactions. The Rate Constants for the Carboxylation of Grignard Reagents

Article abstract of DOI:10.1246/cl.1993.525

The rate constants for the carboxylation of a series of aliphatic Grignard reagents were measured as part of the development of a computer assisted automated synthesis apparatus.A good correlation was obtained between the rate constants and Taft's Es values.