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ChemComm
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COMMUNICATION
Journal Name
In summary, we have developed a protocol for palladium-
catalyzed relay Heck-type reaction of fluoroalkyl bromides to
synthesize remote fluoroalkyl alkenes via 1,5-HAT strategy.
This method provides a direct way for highly site selective
remote C-H activation and highly efficient access to 1,5-
fluoroalkyl alkenes in moderate to good yields. Further
investigation of remote functionalization of alkenes via 1,5-
HAT strategy with [Pd/Xantphos] complex through a SET
pathway is underway in our laboratory.
Xie, S. Yu and C. Zhu, Chem. Soc. Rev., D2O01I:81,04.1703, 96/5C49.CC10048B
11 (a) L. Li, H. Luo, Z. Zhao, Y. Li, Q. Zhou, J. Xu, J. Li and Y.-N. Ma,
Org. Lett., 2019, 21, 9228; (b) L. Li, Y. Li, Z. Zhao, H. Luo and Y.-
N. Ma, Org. Lett., 2019, 21, 5995.
Conflicts of interest
There are no conflicts to declare.
Acknowledgements
The authors are grateful for the financial support from the
National Natural Science Foundation of China (21801065,
21602190), Foundation of Henan Province Department of
Science and Technology (192102310031, 172102210456).
Notes and references
1
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