
Journal of Organic Chemistry p. 2605 - 2606 (1991)
Update date:2022-08-17
Topics:
Buechi, George
Galindo, Jose
A new, regioselective synthesis of alkylpyrazines begins with condensation of α-oximido carbonyl compounds with allylamines.The resulting imines are isomerized in the presence of potassium tert-butoxide to the corresponding 1-hydroxy-1,4-diazahexatrienes.Thermal electrocyclization-aromatization to pyrazines is best performed after O-acylation of the oximes with methyl chloroformate.
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