Selective N-functionalization of 6-substituted-2-pyridones

DOI: 10.1016/0040-4039(95)01917-7

Source and publish data:

Tetrahedron Letters p. 8917 - 8920 (1995)

Update date:2022-08-11

Topics:

Authors:

Hui, Liu

Sung-Bo, Ko

Josien, Hubert

Curran, Dennis P.

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Article abstract of DOI:10.1016/0040-4039(95)01917-7

6-Substituted-2-pyridones can be selectively N-alkylated by treatment with NaH/LiBr in a mixture of DMF and DME. Yields of N-propargylated, N-allylated, and other N-functionalized products are good, and only small amounts of the isomeric O-alkylated produ

Full text of DOI:10.1016/0040-4039(95)01917-7

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