13C NMR Spectra of 5β,14β-Hydroxysteroids

Article abstract of DOI:10.1002/mrc.1260231115

The 13C chemical shifts of 30 substituted 5β,14β-hydroxysteroids are described and discussed.Substituent chemical shifts for 12α- and 12β-hydroxy groups were evaluated, and interesting γ effects were observed.A correlation is shown to exist between the 1H shifts of H-17 and the 13C shifts of C-17 for various C-12 substituents.A relationship for the distance of the substituent at C-12 from H-17 in the 14β,20-lactones was demonstrated, where an increased distance between these atoms is associated with smaller shift differences.