An expedient protocol of the Biginelli dihydropyrimidine synthesis using carbonyl equivalents

Article abstract of DOI:10.1016/S0040-4020(99)00760-7

A one - pot condensation of perhydro-1,3 heterocycles - aldehyde equivalents with ethyl acetoacetate and ureas provides a convenient synthesis of the title compounds with a variety of substituents at C-4. Yields are equivalent or significantly higher than