Angewandte Chemie International Edition
10.1002/anie.201705724
COMMUNICATION
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Figure 5. Time dependent absorption change monitored at 550 nm and 30 °C
as a result of thrombin-catalyzed hydrolysis of fibrinogen. The effect of tba20-
L
4
on the clotting time is compared in the presence (red circles) and absence
II
(
(
blue circles) of Cu . Black circles: tba15; grey circles: control without DNA
both in the presence of Cu ; [DNA] = 1.1 µM in all experiments).
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(
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a
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Keywords: bioinorganic chemistry • G-quadruplexes • metal
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