The Reductive Coupling of Organic Halide Using Hydrazine and a Palladium Amalgam Catalyst. I. The Preparation of Biaryls

Article abstract of DOI:10.1246/bcsj.53.1767

Iodoarenes could be converted to the corresponding biaryls in high yields by use of a catalytic amount of a palladium amalgam in place of a palladium-calcium carbonate catalyst in Busch's reaction.The 2,3'-isomer content in the bitolyls obtained by the homo-coupling of o-iodotoluene was 15percent when palladium was used, while it was 1percent when a palladium amalgam was used, and the latter was re-usable.The present method is further applicable to some iodoalkanes.