Zirconyl chloride: An efficient, water-tolerant, and reusable catalyst for the synthesis of N-methylamides

Article abstract of DOI:10.1055/s-0030-1260796

ZrOCl₂8H₂O is a highly effective, water-tolerant, and reusable catalyst for the direct condensation of carboxylic acids and N,N-dimethylurea under microwave irradiation to give the corresponding N-methylamides in moderate to excellent yields. Notably, ZrOCl ₂8H₂O is a potentially useful green catalyst due to its low toxicity, easy availability, low cost, ease of handling, easy recovery, good activity, and reusability. Georg Thieme Verlag Stuttgart ? New York.