Tetrahedron Letters p. 1847 - 1850 (1987)
Update date:2022-08-29
Topics:
Katritzky, Alan R.
Sengupta, Saumitra
1-Trimethylsilylmethanol is used via its lithiated lithium carbonate in a one-pot procedure to hydroxymethylate esters, dimethylamides, acid chlorides and nitriles to give the corresponding hydroxymethyl carbonyl compounds in the synthetic conversion RCOX -> RCOCH2OH.
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