1
4.55.
Ethyl 6-methyl-2-oxo-4-(p-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate (4n)19
Yield: 296 mg (92%); White solid, mp 172-173 ℃.
1H NMR (500 MHz, DMSO) δ 10.33 (s, 1H), 9.63 (s, 1H), 7.14 (d, J = 8.6 Hz, 2H), 6.91 (d, J = 8.7 Hz, 2H), 5.12 (s, 1H), 4.00 (q, J = 7.1 Hz,
2
H), 3.72 (s, 3H), 2.30 (s, 3H), 1.11 (t, J = 7.1 Hz, 3H).
13C NMR (126 MHz, DMSO) δ 193.66, 151.52, 151.07, 146.75, 146.29, 140.64, 131.14, 128.25, 127.37, 127.25, 123.48, 108.06, 62.81, 54.31,
1
8.48.
5
-Acetyl-4-(4-methoxyphenyl)-6-phenyl-3,4-dihydropyrimidin-2(1H)-one (4o)17
Yield: 281.5 mg (92%); Yellow solid, mp 140-142 ℃.
1H NMR (500 MHz, DMSO) δ 10.33 (s, 1H), 9.63 (s, 1H), 7.14 (d, J = 8.6 Hz, 2H), 6.91 (d, J = 8.7 Hz, 2H), 5.12 (s, 1H), 4.00 (q, J = 7.1 Hz,
2
H), 3.72 (s, 3H), 2.30 (s, 3H), 1.11 (t, J = 7.1 Hz, 3H).
13C NMR (126 MHz, DMSO) δ 174.45, 165.62, 159.19, 145.24, 136.17, 128.09, 114.33, 101.39, 60.02, 55.54, 53.91, 17.61, 14.50.
5
Acknowledgments
This project was supported by the National Natural Science Foundation of China (Nos. 21462001 and 11765002), the Science and Technology
Projects of Jiangxi (No. 20161BCB24006), and the Science and Technology Foundation of the Jiangxi Education Department (Nos. KJLD14050,
GJJ150584).
6
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