Synthesis of (±)-dibenzocyclooctadiene lignans, (±)-schizandrin, (±)- gomisin A and their stereoisomers, utilizing the samarium-Grignard reaction

DOI: 10.1248/cpb.42.430

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 430 - 437 (1994)

Update date:2022-08-30

Topics:

Authors:

Takeya Takeya

Ohguchi Ohguchi

Ara Ara

Tobinaga

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Article abstract of DOI:10.1248/cpb.42.430

Several (±)-dibenzocyclooctadiene lignans, (±)-schizandrin (1a) (±)- gomisin A (1b), and their stereoisomers 2a and 2b, were synthesized by the samarium-Grignard reaction of the phenylpropyl bromides 4 and the phenylacetone derivative 5 to give the erythro and threo-butanols 6 and 7 followed by oxidative aryl-aryl coupling reaction of each butanol.

Full text of DOI:10.1248/cpb.42.430

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