Synthesis of (±)-dibenzocyclooctadiene lignans, (±)-schizandrin, (±)- gomisin A and their stereoisomers, utilizing the samarium-Grignard reaction

DOI: 10.1248/cpb.42.430

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 430 - 437 (1994)

Update date:2022-08-30

Topics:

Authors:

Takeya Takeya

Ohguchi Ohguchi

Ara Ara

Tobinaga

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.42.430

Several (±)-dibenzocyclooctadiene lignans, (±)-schizandrin (1a) (±)- gomisin A (1b), and their stereoisomers 2a and 2b, were synthesized by the samarium-Grignard reaction of the phenylpropyl bromides 4 and the phenylacetone derivative 5 to give the erythro and threo-butanols 6 and 7 followed by oxidative aryl-aryl coupling reaction of each butanol.

Full text of DOI:10.1248/cpb.42.430

NII-Electronic Library Service

Products guided by the article

Product name:Dibenzo[a,c]cycloocten-6-ol,5,6,7,8-tetrahydro-1,2,3,10,11,12-hexamethoxy-6,7-dimethyl-, (6S,7R,12aR)-

Cas No:114422-18-3

R&D Labs maybe for 114422-18-3

SuZhou Ascepion Pharmaceuticals, Inc.(expird)

Contact:0512-86881668

Address:Building C,68Xingqing Road,Suzhou,China.
STAR SYNTHESIS CO.,LIMITED

Contact:+(852) 301-98033

Address:Flat C, 23/F, Lucky Plaza, 315-321 Lockhart Road, Wan Chai, Hong Kong
Dongtai Xinyuan Chemical Co., Ltd.

Contact:+86-21-56733000

Address:404F, 99Nong No.117 Zhongtan Rd. Shanghai
WD Silicone Co., Ltd

Contact:+86-27-87204219, +86-27-87215023

Address:2402, HuiGu Space-time Building, 8 Forest Road, East Lake Hi-Tech Development Zone
Lianyungang Yunbo Chemical Co.,Ltd.

Contact:518-81066110

Address:B907,Dongsheng"Mingdu Square,21-2 East Chaoyang Road,Xinpu,(sale department)

Relevant to this article

Forging isopeptide bonds using thiol-ene chemistry: Site-specific coupling of ubiquitin molecules for studying the activity of isopeptidases

Doi:10.1021/ja300500a
(2012)
Indium-mediated deoxygenation of amine-N-oxides in aqueous media

Doi:10.1016/S0040-4039(00)00218-5
(2000)
Synergistic Cu/Pd Catalysis for Enantioselective Allylation of Ketimine Esters: The Direct Synthesis of α-Substituted α-Amino Acids and 2H-Pyrrols

Doi:10.1002/adsc.201800986
(2018)
A Small Covalent Allosteric Inhibitor of Human Cytomegalovirus DNA Polymerase Subunit Interactions

Doi:10.1021/acsinfecdis.6b00079
(2017)
Heterogeneous catalysis in ionic liquids: The heck reaction of bromobenzene with styrene over palladium supported on mesoporous carbon

Doi:10.1134/S0965544108050058
(2008)
Thorium-Organic Framework Constructed with a Semirigid Triazine Hexacarboxylic Acid Ligand: Unique Structure with Thorium Oxide Wheel Clusters and Iodine Adsorption Behavior

Doi:10.1021/acs.inorgchem.9b03639
(2020)

Article Doi