Journal of Heterocyclic Chemistry p. 461 - 463 (1997)
Update date:2022-08-11
Topics:
Axelsson, Oskar
Peters, Dan
N-Benzylquinuclidinium bromide was ring opened by a series of heteronucleophiles, in the presence of cesium carbonate, to yield the corresponding N-benzyl-4-(2-hetero-ethyl)piperidines. The best yields were found with thiophenol (56%), phenol (55%), and benzimidazole (38%) as nucleophiles.
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