Structural modifications of 6-naphthalene-2-carboxylate retinoids

DOI: 10.1016/S0960-894X(96)00524-0

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2865 - 2870 (1996)

Update date:2022-08-12

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Authors:

Yu, Kuo-Long

Ostrowski, Jacek

Chen, Simon

Tramposch, Kenneth M.

Reczek, Peter R.

Mansuri, Muzammil M.

Starrett Jr., John E.

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Article abstract of DOI:10.1016/S0960-894X(96)00524-0

The keto linker of 2-naphthoate retinoid 1 has been found nonessential for RAR transactivation activity and can be replaced with heteroatoms such as S, O, N without significant reduction of the activity. On the other hand, substitutions on the aromatic rings of retinoids 1 and 2 resulted in analogs with reduced potentcy and RAR selectivity.

Full text of DOI:10.1016/S0960-894X(96)00524-0

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