STUDIES IN POLYETHER SYNTHESIS USING POLYEPOXYDE CYCLISATIONS.

Article abstract of DOI:10.1016/S0040-4039(00)95630-2

The acid-catalysed directed cyclisation of mono-, di-, and triepoxy t-butyl ester derivatives is used for the asymmetric synthesis of various polyether-type fragments including a C13-C27 fragment of etheromycin.The epoxide stereochemistry is set up by Sharpless epoxidation of allylic and homoallylic alcohols.