Efficient reductive Claisen rearrangement of prop-2’-enyloxyanthraquinones and 2’-chloroprop-2’-enyloxyanthraquinones with iron powder in ionic liquids

Article abstract of DOI:10.3906/kim-1711-49

A rapid and selective iron-mediated reductive Claisen rearrangement of various prop-2’-enyloxyanthraquinones and 2’-chloroprop-2’-enyloxyanthraquinones to 1-hydroxy-2-(prop-2’-enyl)anthraquinones and anthrafurandiones is presented. All reactions are carried out in a mixture of ionic liquids, [Bzmim]Cl (1-benzyl-3-methylimidazolium chloride) and [Hmim]BF4 (1-methylimidazolium tetrafluoroborate), in short reaction times (5–35 min). Our study showed that 1-(prop-2’-enyloxy)anthraquinone is more active than 1-(2’-chloroprop-2’-enyloxy)anthraquinone to perform this rearrangement.

Full text of DOI:10.3906/kim-1711-49

Turk J Chem
2018) 42: 883 – 895
Turkish Journal of Chemistry
(
http://journals.tubitak.gov.tr/chem/
¨
˙
⃝
c TUBITAK
Research Article
doi:10.3906/kim-1711-49
Efficient reductive Claisen rearrangement of prop-2’-enyloxyanthraquinones and
2
’-chloroprop-2’-enyloxyanthraquinones with iron powder in ionic liquids
∗
Samaneh NADALI, Ali KHOSHROO, Ghasem AGHAPOUR
School of Chemistry, Damghan University, Damghan, Iran
Received: 13.11.2017
•
Accepted/Published Online: 02.04.2018
•
Final Version: 01.06.2018
Abstract: A rapid and selective iron-mediated reductive Claisen rearrangement of various prop-2’-enyloxyanthraquinones
and 2’-chloroprop-2’-enyloxyanthraquinones to 1-hydroxy-2-(prop-2’-enyl)anthraquinones and anthrafurandiones is pre-
sented. All reactions are carried out in a mixture of ionic liquids, [Bzmim]Cl (1-benzyl-3-methylimidazolium chloride)
and [Hmim]BF
-(prop-2’-enyloxy)anthraquinone is more active than 1-(2’-chloroprop-2’-enyloxy)anthraquinone to perform this rear-
rangement.
4
(1-methylimidazolium tetrafluoroborate), in short reaction times (5–35 min). Our study showed that
1
Key words: 2’-Chloroprop-2’-enyloxyanthraquinone, anthrafurandione, Claisen rearrangement, iron, ionic liquid
1. Introduction
Synthesis of anthraquinone (AQ) derivatives constitutes a very important field in organic chemistry due
to their various desired properties such as antimicrobial and antiviral,1 anticancer,
2−4
antiinflammatory,5
antimalarial,6 antifungal,7 laxative,8 antioxidant,9 and antiarthritic,10 and also their important industrial ap-
plications (e.g., textile dyestuffs,11 pulping additives,12 and colorimetric sensor systems13,14). In this regard,
the reductive Claisen rearrangement of prop-2’-enyloxyanthraquinones has become a standard strategy for the
functionalization of anthraquinones and synthesis of their desired derivatives.1
5−19
This rearrangement has
been performed using different reagents such as sodium dithionate15 and glucose.19 However, some described
methods suffer from several disadvantages such as the formation of anthracenone derivatives as byproducts, loss
of the methoxy group attached to the anthraquinone core, isomerization or even reduction of the allyl side chain
double bond in rearranged products, and long reaction times.15
We previously performed this rearrangement on the allyloxyanthraquinones with silver/potassium io-
dide as a reagent in acetic acid.20 Also, very recently we carried out this rearrangement on the propargy-
loxyanthraquinones affording anthrafurandiones.21 Now with these descriptions and also with respect to our
interest in applying ionic liquids in organic synthesis as environmentally friendly solvents,22,23 we report an
efficient and selective method for the reductive Claisen rearrangement of prop-2’-enyloxyanthraquinones and
2’-chloroprop-2’-enyloxyanthraquinones to 1-hydroxy-2-(prop-2’-enyl)anthraquinones and anthrafurandiones re-
spectively using iron powder. All reactions are performed in a mixture of two ionic liquids containing 1-
benzyl-3-methylimidazolium chloride [Bzmim]Cl and 1-methylimidazolium tetrafluoroborate [Hmim]BF24 in
4
short reaction times (Figure 1).
∗
Correspondence: gh aghapour@du.ac.ir
8
83

NADALI et al./Turk J Chem
Figure 1. Reductive Claisen rearrangement of 1 and 20 to products 2 and 21 respectively using iron powder in a
mixture of two ionic liquids, [Hmim]BF
4
and [Bzmim]Cl.
2. Results and discussion
We performed reductive Claisen rearrangement of 1-(prop-2’-enyloxy)anthraquinone (1) using iron powder (2
◦
equiv.) in a mixture of two ionic liquids [Hmim]BF4 and [Bzmim]Cl at 110 C. Under these reaction conditions,
1-hydroxy-2-(prop-2’-enyl)anthraquinone (2) was produced in 98% yield after only 8 min. However, this reaction
◦
was unsuccessful in the absence of iron (i.e. thermal conditions), [Hmim]BF4 , or [Bzmim]Cl at 110 C, affording
the rearranged product (2) in less than 10% yields after 70 min. In addition, the yield of this reaction decreased
◦
to 50% at 90 C. Also, when potassium chloride was used instead of [Bzmim]Cl in this rearrangement, the
desired product (2) was formed in only 25% yield after 9 min. Therefore, we performed the reductive Claisen
rearrangement of various prop-2’-enyloxyanthraquinones to their corresponding rearranged products using the
above mentioned conditions. The results are shown in Table 1. These prop-2’-enyloxyanthraquinones were
synthesized from the reaction of the related hydroxyanthraquinones with allyl bromide in the presence of
anhydrous potassium carbonate in refluxing acetone as solvent.16
As shown in Table 1, the reductive Claisen rearrangement of the prop-2’-enyloxyanthraquinones was read-
ily carried out in good to excellent yields (52%–98%) in short reaction times (5–35 min), affording the rearranged
products 1-hydroxy-2-(prop-2’-enyl)anthraquinones. Most notably, no side chain double bond isomerization or
reduction in the rearranged products, anthracenone formation, or loss of the methoxy group attached to the
anthraquinone core was observed in this rearrangement. Moreover, it was possible to perform selectively mono
or double Claisen rearrangements of bis(prop-2’-enyloxy)anthraquinone systems with controlling of the molar
ratio of the reductant or reaction time (in Table 1, compare entries 3 with 4, 7 with 8, and 10 with 11).
With slight modification of the present procedure, we accomplished the reductive Claisen rearrangement
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NADALI et al./Turk J Chem
Table 1. Reductive Claisen rearrangement of prop-2’-enyloxyanthraquinones with iron in a mixture of two ionic liquids,
◦
[
Hmim]BF
4
and [Bzmim]Cl, at 110 C.
Entry
no.
Molar ratio
AQ: Fe
Time
(min)
Yield
a
(%)
Substrate
Product
1
2
3
1:2
1:3
1:2
8
98
83
64
35
10
4
1:4
15
83
5
1:2
23
78
6
1:2
11
91
8
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NADALI et al./Turk J Chem
Table 1. Continued.
Entry
no.
Molar ratio
AQ: Fe
Time
(min)
Yield
a
(%)
Substrate
Product
7
1:2
5
55
8
1:4
6
97
9
1:2
8
82
1
0
1:2
6
52
1
1
1:2
20
84
a
Isolated yields.
of 2’-chloroprop-2’-enyloxyanthraquinones in short reaction times (7–25 min). All reactions produced anthrafu-
randiones as major products in moderate to good yields (Table 2) instead of the expected rearranged products,
such as 2-(2’-chloroprop-2’-enyl)-1-hydroxyanthraquinone (42) (Figure 2).
In some reactions, we observed the formation of 1-hydroxyanthraquinone derivatives stemming from de-
protection of starting anthraquinones. For example, in treatment of 1-(2’-chloroprop-2’-enyloxy)anthraquinone
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NADALI et al./Turk J Chem
Table 2. Reductive Claisen rearrangement of 2’-chloroprop-2’-enyloxyanthraquinones with iron in a mixture of two ionic
◦
liquids, [Hmim]BF
4
and [Bzmim]Cl, at 160 C.
Entry
Molar ratio
AQ : Fe
Time
(min)
Yield
a
(%)
Substrate
Product
no.
8
1
2
5
1
1:2
20
2
3
1:2
10
83
1
:2
10
71
6
2
4
1:1
16
3
6
8
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NADALI et al./Turk J Chem
Table 2. Continued.
Entry
no.
Molar ratio
AQ : Fe
Time
(min)
Yield
a
(%)
Substrate
Product
9
5
3
5
1:2
10
4
1
5
0
6
1
:2
15
5
3
5
4
8
7
1:1
20
888

NADALI et al./Turk J Chem
Table 2. Continued.
Entry
no.
Molar ratio
AQ : Fe
Time
(min)
Yield
a
(%)
Substrate
Product
8
1
6
1
8
1:2
7
4
4
7
5
9
1:4
25
a
Isolated yields.
Figure 2. 2-(2’-Chloroprop-2’-enyl)-1-hydroxyanthraquinone (42).
◦
(
20) with iron powder (2 equiv.) in a mixture of [Hmim]BF4 and [Bzmim]Cl at 160 C, 2-methyl-6,11-
dihydroanthra[1,2-b]furan-6,11-dione (21) was produced in 82% yield with concomitant formation of 1-hydrox-
yanthraquinone (38) in 15% yield after 20 min. However, this reaction was unsuccessful in the absence of
◦
iron (i.e. thermal conditions), [Hmim]BF4 , or [Bzmim]Cl at 160 C again. In these attempts, 20 remained
8
89

NADALI et al./Turk J Chem
completely intact after 2 h. Moreover, we did not observe the formation of an anthracenone derivative or loss
of the methoxy group attached to the anthraquinone core (entry 6) in the reactions given in Table 2. Starting
2’-chloroprop-2’-enyloxyanthraquinones were easily synthesized by the reaction of the corresponding hydroxyan-
thraquinones with 2, 3-dichloroprop-1-ene in the presence of anhydrous potassium carbonate in DMF as solvent
at 70 C with reaction times up to 40 h.25
◦
Then we decided to study the activity difference between prop-2’-enyloxy and 2’-chloroprop-2’-enyloxy
groups in reductive Claisen rearrangement. For this purpose, reductive Claisen rearrangement of 1 was studied
◦
in the presence of 20 (1:1) at 110 C via the present method. The result and conversion yield of this selective
reaction is shown in Figure 3.
4
Figure 3. Selectivity between 1 and 20 in the reductive Claisen rearrangement using Fe/[Hmim]BF /[Bzmim]Cl at
◦
1
10 C.
As shown in this figure, reductive Claisen rearrangement of 1 is carried out in the presence of 20 in good
selectivity, indicating that the prop-2’-enyloxy group is more active than the 2’-chloroprop-2’-enyloxy group in
this rearrangement.
The proposed mechanism of these reactions is shown in Figure 4. First the anthraquinone core is
reduced using iron powder in the presence of [Bzmim]Cl and [Hmim]BF4 to its electron-rich hydroquinone
intermediate A that easily performs this rearrangement. Intermediate C is formed after rearrangement followed
by enolization. In this intermediate (if X = Cl), the OH group ortho to the allyl group is added to the double
bond of this side chain, affording intermediate D. This internal cyclization in acidic media followed by HCl
elimination leads to intermediate E containing furan moiety. Finally, product 2 or 21 is produced by air
oxidation of intermediate C (X = H) or intermediate E, respectively. As mentioned above, these reactions were
unsuccessful in the absence of iron (i.e. thermal conditions), [Hmim]BF4 , or [Bzmim]Cl. These results confirm
the reductive nature of this rearrangement via electron transfer from iron to anthraquinone core (Figure 4, step
1), which is facilitated by theses ionic liquids. Also, when the rearrangement of 20 was performed under N2
atmosphere via the present method, desired product 21 was produced in only 20% yield together with 38 in
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NADALI et al./Turk J Chem
40% yield after 20 min. This result also indicates the importance of air oxidation to produce the final product
and is in accordance with the present mechanism (Figure 4, final step).
Figure 4. The proposed mechanism of the reductive Claisen rearrangement of prop-2’-enyloxyanthraquinones and
2
4
’-chloroprop-2’-enyloxyanthraquinones using Fe/[Hmim]BF /[Bzmim]Cl.
8
91

NADALI et al./Turk J Chem
In conclusion, the present investigation has demonstrated that prop-2’-enyloxyanthraquinones and also
’-chloroprop-2’-enyloxyanthraquinones can be easily rearranged to their corresponding 1-hydroxy-2-(prop-2’-
2
enyl)anthraquinones and anthrafurandiones respectively by the reductive Claisen rearrangement using iron
powder. With respect to the important uses of ionic liquids in organic synthesis as environmentally friendly
solvents, this rearrangement is carried out in [Bzmim]Cl under an acidic condition created by [Hmim]BF4 in
moderate to excellent yields and in short reaction times. Most notably, in contrast to some previous works,15
no anthracenone formation or loss of methoxy group attached to the anthraquinone core was observed in these
rearrangements. Also, it is possible to execute mono or double Claisen rearrangement selectively in bis(prop-2’-
enyloxy)anthraquinone systems while controlling the molar ratio of the reductant or reaction time. In addition,
it was found that the prop-2’-enyloxy group is more active than the 2’-chloroprop-2’-enyloxy group in this
rearrangement via the present method.
3. Experimental
Solvents, reagents, and chemicals were obtained from Merck, Fluka, or Aldrich chemical companies. Some
substrates and all products are known compounds1
6,20,21,26−29
and were characterized by comparison of their
physical or spectral data with authentic samples. Physical and spectral data for new substrates have been given
below. Fourier transform-infrared spectra were recorded on a PerkinElmer RXI spectrophotometer. Nuclear
magnetic resonance (NMR) spectra were recorded on a Bruker Avance 300 and 500 spectrometer. UV/Vis
spectra were obtained with an Analytik Jena SPECORD 205 spectrometer. Elemental analysis was performed
using an Elementar Vario EL III analyzer. Melting points were determined in open capillary tubes in an
Electrothermal 9100 melting point apparatus. Thin-layer chromatography (TLC) was carried out on silica gel
254 analytical sheets obtained from Fluka.
3.1. Typical procedure for the reductive Claisen rearrangement of 1-(prop-2’-enyloxy)anthraquino-
ne (1) to 1-hydroxy-2-(prop-2’-enyl)anthraquinone (2)
1-(Prop-2’-enyloxy)anthraquinone (1) (1 mmol, 0.264 g) and iron powder (2 mmol, 0.11 g) were added to a
flask containing a mixture of two ionic liquids, 1-methylimidazolium tetrafluoroborate [Hmim]BF4 (5 mmol,
◦
0
.85 g) and 1-benzyl-3-methylimidazolium chloride [Bzmim]Cl (3 mmol, 0.625 g), in an oil bath at 110 C. The
reaction mixture was stirred for 8 min in order to complete the reaction, as determined by TLC. The reaction
mixture was cooled to room temperature and then filtered after addition of CH2 Cl2 (2 × 20 mL). The organic
layer was washed with water (50 mL), saturated NaHCO3 (50 mL) and brine (50 mL). 1-Hydroxy-2-(prop-2’-
enyl)anthraquinone (2) was obtained after drying and evaporation of the organic solvent in 98% yield (0.258
g); yellow needles (from acetone), mp = 121–122 C (lit.26 120–120.5 C).
◦
◦
3.2. Typical procedure for the reductive Claisen rearrangement of 1-(2’-chloroprop-2’-enyloxy)
anthraquinone (20) to 2-methyl-6,11-dihydroanthra[1,2-b]furan-6,11-dione (21)
1-(2’-Chloroprop-2’-enyloxy)anthraquinone (20) (1 mmol, 0.3 g) and then iron powder (2 mmol, 0.11 g) were
added to a flask containing a mixture of two ionic liquids, 1-methylimidazolium tetrafluoroborate [Hmim]BF4
(
5 mmol, 0.85 g) and 1-benzyl-3-methylimidazolium chloride [Bzmim]Cl (6 mmol, 1.25 g), in an oil bath at
◦
1
60 C. The reaction mixture was stirred for 20 min to complete the reaction, as determined by TLC. The
reaction mixture was cooled to room temperature and then filtered after addition of CH2 Cl2 (2 × 20 mL).
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NADALI et al./Turk J Chem
The organic layer was washed with water (50 mL), saturated NaHCO3 (50 mL), and brine (50 mL). 2-Methyl-
6,11-dihydroanthra[1,2-b]furan-6,11-dione (21) was isolated after evaporation of organic solvent and column
chromatography of the crude mixture on silica gel 60 using n-hexane-ethyl acetate (30:1) as eluent in 82% yield
0.21 g); mp = 191–193 C (lit.29 192–193 C). Also, 1-hydroxyanthraquinone (38) was isolated using this
◦
◦
(
column chromatography in 15% yield (0.034 g).
3
3
.3. Data
.3.1. 1-(2’-Chloroprop-2’-enyloxy)-4-methoxyanthraquinone (24)
Orange needles; mp = 142–144 C; 1 H NMR (CDCl3 , 500 MHz): δ 3.94 (s, 3H), 4.64 (s, 2H), 5.46 (d, 1H, J =
◦
1
1
1
.1 Hz), 5.85 (d, 1H, J = 1.4 Hz), 7.26 (m, 2H), 7.64–7.66 (m, 2H), 8.09–8.11 (m, 2H), ppm; 13 C NMR (CDCl3 ,
25 MHz): δ 57.10, 72.51, 114.59, 119.91, 123.13, 123.58, 124.22, 126.60, 126.71, 133.53, 133.65, 134.18, 134.39,
35.68, 152.05, 155.33, 183.24, 183.40 ppm; IR(KBr): 3125 (w), 2919 (w), 2848 (w), 1666 (s), 1646 (w), 1567
−
1
(
w), 1435 (w), 1404 (w), 1322 (m), 1270 (s), 1251 (s), 1059 (m), 987 (m), 817 (w), 724 (m) cm ; UV (MeOH),
λmax (log ε): 204 (4.28), 221 (4.29), 251 (4.30), 412 (3.61) nm; Anal. Calcd for C18 H13 O4 Cl: C, 65.75; H,
.95. Found: C, 64.88; H, 3.58.
3
3.3.2. 1-(2’-Chloroprop-2’-enyloxy)-8-hydroxyanthraquinone (28)
Yellow-orange powder; mp = 133–135 C; 1 H NMR (CDCl3 , 500 MHz): δ 4.69 (s, 2H), 5.49–5.50 (d, 1H, J =
◦
1.4 Hz), 5.95 (d, 1H, J = 1.65 Hz), 7.18–7.23 (m, 2H), 7.53–7.56 (m, 1H), 7.64–7.70 (m, 2H), 7.91–7.93 (m,
1
H), 12.87 (s, 1H) ppm; 13 C NMR (CDCl3 , 125 MHz): δ 70.98, 114.40, 117.12, 119.08, 119.79, 121.18, 121.36,
124.97, 132.75, 134.66, 135.87, 135.96, 136.14, 158.82, 162.65, 182.63, 188.64 ppm; IR (KBr): 3422 (br), 3114
(
(
w), 2924 (m), 2856 (w), 1669 (m), 1638 (s), 1587 (m), 1448 (m), 1289 (s), 1239 (s), 1025 (m), 843 (w), 744
−
1
m) cm ; UV (MeOH), λmax (log ε): 222 (4.48), 254 (4.30), 409 (3.83) nm; Anal. Calcd for C17 H11 O4 Cl:
C, 64.86; H, 3.49. Found: C, 63.95; H, 3.19.
3.3.3. 1-(2’-Chloroprop-2’-enyloxy)-8-methoxyanthraquinone (30)
Yellow powder; mp = 138–140 C; 1 H NMR (CDCl3 , 500 MHz): δ 3.94 (s, 3H), 4.69 (s, 2H), 5.44 (d, 1H,
J = 1.1 Hz), 5.85 (d, 1H, J = 1.5 Hz), 7.18–7.25 (m, 2H), 7.54–7.60 (m, 2H), 7.77–7.83 (m, 2H) ppm; 13
NMR (CDCl3 , 125 MHz): δ 56.78, 71.22, 114.27, 118.25, 119.21, 120.34, 120.46, 124.02, 124.80, 126.70, 133.99,
◦
C
1
1
34.23, 134.93, 135.05, 157.56, 159.68, 182.57, 183.94 ppm; IR (KBr): 3018 (w), 2925 (w), 2856 (w), 1670 (s),
−1
647 (m), 1589 (m), 1325 (s), 1290 (s), 1240 (s), 1064 (m), 986 (s), 818 (w), 742 (m) cm ; UV (MeOH), λmax
(
log ε): 222 (4.67), 256 (4.49), 382 (3.92) nm; Anal. Calcd for C18 H13 O4 Cl: C, 65.75; H, 3.95. Found: C,
5.62; H, 3.68.
6
3.3.4. 1,8- Bis(2’-chloroprop-2’-enyloxy)anthraquinone(32)
Yellow needles; mp = 161–163 C; 1 H NMR (CDCl3 , 300 MHz): δ 4.72 (s, 4H), 5.51–5.52 (d, 2H, J = 1.38
◦
Hz), 5.97–5.98 (d, 2H, J = 1.6 Hz), 7.24–7.27 (m, 2H), 7.60–7.65 (m, 2H), 7.86–7.89 (m, 2H) ppm; 13 C NMR
(
CDCl3 , 75 MHz): δ 70.89, 113.81, 120.03, 120.09, 124.45, 133.92, 134.78, 134.80, 157.26, 181.85, 183.43 ppm;
IR (KBr): 3094 (w), 3032 (w), 2909 (w), 2854 (w), 1665 (s), 1640 (m), 1588 (s), 1447 (m), 1322 (s), 1287 (s),
8
93

NADALI et al./Turk J Chem
−
1
1
238 (s), 1076 (m), 999 (m), 903 (m), 836 (w), 743 (m) cm ; UV (MeOH), λmax (log ε): 286 (3.09), 376
(
3.79) nm; Anal. Calcd for C20 H14 O4 Cl2 : C, 61.69; H, 3.60. Found: C, 61.36; H, 3.21.
3.3.5. 1-(2’-Chloroprop-2’-enyloxy)-5-hydroxyanthraquinone (34)
Yellow powder; mp = 140–143 C; 1 H NMR (CDCl3 , 500 MHz): δ 4.77 (s, 2H), 5.57 (s, 1H), 6.03 (s, 1H),
◦
7
1
1
1
.25–7.33 (m, 2H), 7.66–7.80 (m, 3H), 8.03–8.05 (d, 1H, J = 7.75 Hz), 12.46 (s, 1H) ppm; 13 C NMR (CDCl3 ,
25 MHz): δ 70.96, 114.27, 115.61, 119.41, 120.33, 120.53, 123.06, 123.15, 134.64, 134.90, 134.99, 135.52, 136.97,
58.43, 162.09, 181.31, 188.36 ppm; IR (KBr): 3415 (br), 3022 (w), 2925 (s), 2856 (s), 1656 (m), 1631 (m),
−
1
621 (m), 1605 (m), 1587 (m), 1454 (m), 1288 (m), 1264 (s), 1103 (s), 1023 (s), 860 (w), 779 (w) cm ; UV
MeOH), λmax (log ε): 294 (2.73), 402 (3.52) nm; Anal. Calcd for C17 H11 O4 Cl: C, 64.86; H, 3.50. Found:
(
C, 63.79; H, 3.30.
Acknowledgment
We gratefully acknowledge the support of this work by the Damghan University Research Council.
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