Biotransformation of tetrahydroberberine to berberine by enzymes prepared from cultured coptis japonica cells

Article abstract of DOI:10.1016/S0031-9422(00)80807-9

Crude enzymes were extracted from cultured Coptis japonica cells producing large amounts of berberine. One of the enantiomers of tetrahydroberberine, (S)-(-)-tetrahydroberberine, was dehydrogenated to berberine by the enzyme system.