Design and synthesis of simple, yet potent and selective non-ring-A pyripyropene A-based inhibitors of acyl-coenzyme A: Cholesterol acyltransferase 2 (ACAT2)

DOI: 10.1039/c5ob02019k

Source and publish data:

Organic and Biomolecular Chemistry p. 747 - 751 (2015)

Update date:2022-08-11

Topics:

Authors:

Zhan, Yang

Zhang, Xiao-Wei

Xiong, Ying

Li, Bo-Liang

Nan, Fa-Jun

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Article abstract of DOI:10.1039/c5ob02019k

A series of pyripyropene A-based compounds were designed and synthesized by opening the upper section of the A-ring, which significantly simplifies the structure and synthesis from commercially available starting materials. Representative compound (-)-3 exhibited potent activity against ACAT2 and greater selectivity for ACAT2 than for ACAT1.

Full text of DOI:10.1039/c5ob02019k

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