ORGANIC REACTIONS AT HIGH PRESSURE. INTERCONVERSION OF PREVITAMIN D3 AND VITAMIN D3.

Article abstract of DOI:10.1016/0040-4039(88)85075-5

The interconversion of previtamin D₃ and vitamin D₃ at 20 deg C was effected at high pressure (15 kbar) in three solvent mixtures.The rate constants of k₁ and k₂ were determined to be 30 to 45 times larger than the corresponding 1 bar rate constants.The ΔV^* was calculated to be -5.14 cm³/mol or lower, indicating a concerted <1,7> sigmatropic hydrogen shift.