Synthesis of congeners and prodrugs. 3. Water-soluble prodrugs of taxol with potent antitumor activity

DOI: 10.1021/jm00124a011

Source and publish data:

Journal of Medicinal Chemistry p. 788 - 792 (1989)

Update date:2022-08-02

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Authors:

Deutsch Deutsch

Glinski Glinski

Hernandez

Haugwitz

Narayanan

Suffness

Zalkow Zalkow

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Article abstract of DOI:10.1021/jm00124a011

Taxol has shown good in vivo antitumor activity in a number of test systems. The formulation of taxol for antitumor testing has been difficult. Esterification at either C-2' or C-7 resulted in loss of in vitro tubulin assembly activity but not cytotoxicit

Full text of DOI:10.1021/jm00124a011

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