Synthesis of chiral α-acetylenic cyclic amines from α-amino acids: Applications to differentially constrained oxotremorine analogues as muscarinic agents

Article abstract of DOI:10.1016/S0040-4039(00)94471-X

Application of the Cory-Fuchs reaction on Boc-prolinal, Boc-4-hydroxyprolinal, Boc-piperidinal and Boc-serinal derivatives to give chiral 2-pyrrolidinyl-, 2-piperidinyl- and 4-oxazolidinyl-acetylene derivatives provided rapid access to a number of differentially constrained oxotremorine analogues as muscarinic agents.