Chemoselective synthesis of dithymidine phosphorothioate in solution using O-protected thiophosphate monomers

Article abstract of DOI:10.1080/07328319908044676

Diastereomerically pure O-protected thymine monothioate nucleotide (I) is efficiently coupled to protected thymidine (II) in a chemoselective, but not stereoselective manner, to give dithymidine phosphorothioates (III).

Full text of DOI:10.1080/07328319908044676

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Nucleosides and Nucleotides
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Chemoselective Synthesis of Dithymidine
Phosphorothioate in Solution Using O-
Protected Thiophosphate Monomers
a
a
a
Thomas Boesen , Jan Kehler & Otto Dahl
a
Department of Chemistry , University of Copenhagen, The H.
C. Ørsted Institute , Universitetsparken 5, DK-2100, Copenhagen,
Denmark
Published online: 04 Oct 2006.
To cite this article: Thomas Boesen , Jan Kehler & Otto Dahl (1999) Chemoselective Synthesis of
Dithymidine Phosphorothioate in Solution Using O-Protected Thiophosphate Monomers, Nucleosides
and Nucleotides, 18:6-7, 1241-1242, DOI: 10.1080/07328319908044676
To link to this article: http://dx.doi.org/10.1080/07328319908044676
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