A Convenient Synthesis of Nucleoside 3'-H-Phosphonate Monoesters Using Triphosgene

DOI: 10.1016/0040-4039(95)01383-S

Source and publish data:

Tetrahedron Letters p. 6803 - 6806 (1995)

Update date:2022-08-18

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Authors:

Bhongle, Nandkumar N.

Tang, Jin Yan

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Article abstract of DOI:10.1016/0040-4039(95)01383-S

A practical method for the preparation of deoxyribonucleoside and ribonucleoside 3'-H-phosphonate monoesters via triphosgene-mediated coupling of nucleosides to phosphonic acid is described.

Full text of DOI:10.1016/0040-4039(95)01383-S

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Product name:Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 3'-(hydrogen phosphonate), compd. with N,N-diethylethanamine (1:1)

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