Beilstein Journal of Organic Chemistry p. 1220 - 1225 (2015)
Update date:2022-08-11
Topics:
Mei, Qinggang
Wang, Chun
Zhao, Zhigang
Yuan, Weicheng
Zhang, Guolin
The hemisynthesis of the naturally occurring bioactive flavonoid glycoside icariin (1) has been accomplished in eleven steps with 7% overall yield from kaempferol. The 4?-OH methylation of kaempferol, the 8-prenylation of 3-O-methoxymethyl-4?-O-methyl-5- O-prenyl-7-O-benzylkaempferol (8) via para-Claisen-Cope rearrangement catalyzed by Eu(fod)3 in the presence of NaHCO3 , and the glycosylation of icaritin (3) are the key steps.
View MoreContact:+86-574-89075960
Address:#100 Xiang Yun Road, New High tech area, Ningbo, China
Contact:(86) 731 88718666
Address:Room 1222, Unit 4, Building B, Shangcheng, No.47, Kaiyuan East Road.
Zhejiang Haizhou Pharmaceutical Co., Ltd.
website:https://www.haizhoupharma.com/
Contact:+86-576-88221016
Address:No. 19, Donghai 5th Avenue, Yanhai Industrial Zone, Linhai, Zhejiang, China
JIN TAN CHENG'EN CHEMICAL CO.,LTD.
Contact:86-519-82116250
Address:NO.102，village Dongfang，conomic development zone
Hangzhou Showland Technology Co., Ltd.
Contact:86-571-88920516
Address:ROOM2118,NO.553,WENSAN ROAD,HANGZHOU,CHINA
Doi:10.1021/acscatal.0c02731
(2020)Doi:10.1016/j.tetlet.2006.06.038
(2006)Doi:10.1080/15421406.2010.495658
(2010)Doi:10.1016/j.jcat.2009.02.001
(2009)Doi:10.3184/174751915X14206280982837
(2015)Doi:10.1007/s11164-014-1635-4
(2015)
