Journal of Fluorine Chemistry p. 123 - 131 (1990)
Update date:2022-08-10
Topics:
Hamper, Bruce C.
A regioselective route to 1-methyl-3-hydroxy-5-perfluoroalkyl(1H,3H)pyrazoles has been developed.Treatment of perfluoroalkylacetylenic esters with methylhydrazine in methanol-water at 0 deg C or in methylene chloride at low temperature leads to 1-methyl-3-hydroxy-5-perfluoroalkyl(1H,3H)pyrazoles in a regioselective manner.Structural assignments of the regioisomers are based on 13C nmr chemical shifts, long range carbon-fluorine and carbon-proton coupling.The effect of the acetylene structure on the regioselectivity of the reaction is discussed.
View More
website:http://www.mascot-ie.com
Contact:86-519-85010339
Address:B-802,XingBei Building,391#,Tongjiang Middle Road New District,Changzhou,JS,China
WENZHOU M&C FOREIGN TRADE CO.,LTD.
Contact:+86-577-88862917
Address:No.8 Liming West Road,Wenzhou,zhejiang,China
website:http://www.shtopchem.com/
Contact:0086-0576-87776998
Address:room no 1608,xuhui business building yude road,xujiahui street, xuhui district
Shanghai He Yang International Trading Co., Ltd.
Contact:+86-21-52043598
Address:Room 816, Blag.5, No.58 Huachi Road
Chengdu D-Innovation Pharmaceutical Co., Ltd
Contact:86-28-85105536
Address:1001, B6, No.88 Keyuan South Road, Chengdu Hi-Tech Zone
Doi:10.1016/j.inoche.2020.108147
(2020)Doi:10.1016/j.jorganchem.2010.08.011
(2011)Doi:10.1039/c4ob02170c
(2014)Doi:10.1080/00958972.2012.683485
(2012)Doi:10.1039/c5cc09837h
(2016)Doi:10.1016/j.bioorg.2018.11.050
(2019)
