HIGHLY STEREOSELECTIVE SYNTHESIS OF CYCLIC PRIMARY AMINES VIA HYDRIDE REDUCTIONS.

Article abstract of DOI:10.1016/S0040-4039(01)80002-2

The reduction of p,p'-dimethoxybenzhydryl imines of substituted cyclohexanones with lithium tri-sec-butyl or tri-ethylborohydride and subsequent cleavage of the resulting secondary amines with formic acid affords the corresponding axial cyclohexyl primary amines with high stereoselectivity.