'One-pot' preparation of N-(Carbonylamino)amino acids and half- acid/half-ester urea dipeptides directly from α-amino acids

Article abstract of DOI:10.1016/S0040-4039(99)00388-3

N-(Carbonylamino)amino acids and half-acid/half ester urea dipeptides can be prepared in a 'one-pot' sequence directly from α-amino acids by employing TMS as a 'transient' protecting group. The 4-step sequence: selective O-silylation of the α-amino acid,