Synthesis of 1,4-dihydropyridine derivatives having an oxy-, alkoxy-, or dimethylaminophenyl substituent in the 4 position, their antioxidant activity, and their binding to phospholipid membranes

Article abstract of DOI:10.1007/BF01169228

The method of Hantzsch was used to synthesize esters and amides of 2,6-dimethyl-4-aryl- 1,4-dihydropyridine-3,5-dicarboxylic acid, containing electron donor substituents in the phenyl ring. It was found that in addition to their antioxidant properties, 3,5-diamides and 4-(3′,4′-dioxyphenyl) derivatives have an affinity for model phospholipid membranes. 1997 Plenum Publishing Corporation.