A phosphane analog of nedaplatin: Preparation and structural characterization of cis-bis(trimethylphosphane)-(glycolato-O,O′)platinum(II)

Article abstract of DOI:10.1016/S0020-1693(98)00039-5

A water-soluble cis-bis(phosphane)platinum(II) complex, cis-[bis(trimethylphosphane)(glycolato-O,O′)platinum(II)] (1), was crystallized from an organic solvent as a hemihydrate, [Pt(PMe₃)₂(OCH₂COO)] · 0.5H₂O (1 · 0.5H₂O), which is an analog of the anticancer drug, nedaplatin, [Pt(NH₃)₂(OCH₂COO)] (1′). Crystal data at 160(5) K are: C₈H₂₁O_3.5P₂Pt, monoclinic, P2₁ (No. 4), a = 9.012(3), b = 9.824(7), c = 15.417(3) A, β = 97.92(2)°, U = 1351.8(11) A³, Z = 4; those measured at 293(2) K are: a = 9.066(2), b = 9.948(2), c = 15.525(1) A, β = 97.40(1)°, U = 1388.5(4) A³. The glycolate dianion forms a five-membered chelate ring, coordinating to the Pt(II) ion not only at an O atom of the carboxyl group but also at the hydroxy. The NMR spectra show that the hydroxy group ligates to the Pt(II) in the solution of organic solvents as well as in the crystalline state, but that it exchanges with a water molecule in aqueous solution.