Novel conversion of thiols into disulfides, via S-nitrosothiol intermediates using trichloronitromethane

Article abstract of DOI:10.1016/S0040-4020(99)00722-X

An efficient oxidative coupling of thiols to give disulfides via thionitrite (S-nitrosothiol) intermediate is described using trichloronitromethane as efficient reagent in organic solvents and water. Cysteine and glutathione are converted into the corresponding disulfides in water in high yields.