Synthetic Communications p. 2258 - 2269 (2019)
Update date:2022-08-29
Topics:
Gaikwad, Ruchi
Bobde, Yamini
Ganesh, Routholla
Patel, Tarun
Rathore, Anju
Ghosh, Balaram
Das, Kalpataru
Gayen, Shovanlal
Indole derivatives have attractive anticancer properties and may be a future hope for better anticancer drug(s) of low toxicity and high potency. In this paper, syntheses of 2-phenylindole derivatives have been described via Fischer indole synthesis through a one-pot solvent-free method. The synthesized compounds were screened for anticancer potential in vitro against murine melanoma (B16F10), human lung cancer (A549), and human breast cancer (MDA-MB-231) cell lines. The results highlighted that 2-phenylindole derivatives are also promising anticancer agents in case of melanoma and lung cancer along with the breast cancer. Molecular docking analyses with possible targets for melanoma (NEDD4-1) and lung cancer (EGFR) were also performed to understand specific interactions of 2-phenylindole derivatives with the amino acid residues of the receptors.
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