Olefin oxidative cleavage and dioxetane formation using triethylsilyl hydrotrioxide: Applications to preparation of potent antimalarial 1,2,4-trioxanes

Article abstract of DOI:10.1016/S0040-4039(00)92136-1

Oxidative cleavage of alkenyl esters and ethers using Et₃SiOOOH was found to be easier than oxidative cleavage of hydrocarbon alkenes, and Et₃SiOOOH was successfully applied to very short syntheses of new, simple, and potent antimalarial trioxanes 6 and 8.