Stereoselective synthesis of 2-aryloxy acids from lactamide derived esters of racemic α-halo carboxylic acids

Article abstract of DOI:10.1016/0040-4039(96)00391-7

Pyrrolidine derived (S)-lactamide auxiliaries mediate a highly stereoselective coupling reaction between racemic α-haloacids and aryloxides. These amide auxiliaries exhibit enhanced rates of reaction as well as increased degrees of diastereoselection over