Enzymatic oxidative coupling of hydroxyphenylglycine derivatives

Article abstract of DOI:10.1016/S0040-4039(98)01144-7

In contrast to N-protected tyrosine derivatives, N-protected hydroxy-D- phenylglycine derivatives underwent decarboxylation to give 4- hydroxybenzaldehyde under the normal incubation conditions. When both the carboxyl and amino groups of hydroxy-D-phenylglycine are blocked, the C-C and C-O coupling products were obtained in 48% and 32% yields respectively. No racemization of the chiral center was observed for all the substrates examined.