Aziridine-2-carboxylic acid mediated asymmetric synthesis of D-erythro-and L-threo-sphingosine from a common precursor

Article abstract of DOI:10.1016/0040-4039(96)00827-1

Short, two and three step asymmetric syntheses of L-threo- and D-erythrosphingosine (-)-6a and (-)-9a, respectively, in 58 and 31 percent overall yield were accomplished via the stereo and regioselective ring opening of N-sulfinylaziridine 2-carboxylic acid 4. Copyright