Intramolecular Hydrosilylations of β,γ-Unsaturated Acyloxy Silanes. A Convenient Synthesis of (2S,3R)-N-BOC-3-Hydroxyproline Methyl Ester

Article abstract of DOI:10.1016/0040-4039(95)01252-D

A regio- and stereoselective synthesis of hydroxylated carboxylic acids by intramolecular hydrosilylation of β,γ-unsaturated acyloxysilanes has been developed.Application of the methodology in the synthesis of (2S,3R)-3-hydroxy-N-BOC-proline methyl ester is described.