Potent antimitotic and cell growth inhibitory properties of substituted chalcones

Article abstract of DOI:10.1016/S0960-894X(98)00162-0

A series of substituted chalcones was synthesised and screened for cytotoxic activity against the K562 human leukaemia cell line. (E)-3-(3'- Hydroxy-4'-methoxyphenyl)-2-methyl-1-(3',4',5'-trimethoxyphenyl)-prop-2-en- 1-one [IC₅₀ (K562) 0.21 nM] was found to be the most active. A relationship between the conformation and cytotoxicity of the chalcones is discussed.