Carboalumination of 1-Alkynes and in Situ Transmetalation to Higher Order Cyanocuprates. Stereospecific Synthesis of Tri- and Disubstituted Olefins by Conjugate Addition to Enones

Article abstract of DOI:10.1021/jo00292a009

A method is described for the direct carboalumination and in situ cuprate exchange that makes possible the conjugate addition of disubstituted (R, CH3) or monosubstituted (R, H) vinyl anions to α,β-unsaturated ketones.The process results in high yields (63-95percent) of conjugate addition products without the customary intervention of the more standard vinyl iodide and then cuprate formation.