Manganese catalyzed asymmetric oxidation of alkanes to optically active ketones bearing asymmetric center at the α- position

Article abstract of DOI:10.1016/S0040-4039(98)01757-2

Chiral (salen)manganese(III) complex catalyzed oxidation of symmetrical alkanes with iodosylbenzene gives the corresponding optically active ketones (up to 70% ee). The optically active 2-hydroxy-1-indanone (7) thus obtained is a versatile precursor of cis-1-amino-2-indanol (8) which is a key intermediate of chiral auxiliary and anti HIV protease inhibitor (9).