Organic Letters
Letter
generate an unstable aminal, followed by intramolecular condensation
to set up the carbon of ketone at the neighboring carbon (C2).
ACKNOWLEDGMENTS
Financial support by the National Science Foundation of China
21272267), the Fundamental Research Funds for the Central
Universities, the Research Funds of Renmin University of
China (10XNL017), and Beijing National Laboratory for
Molecular Sciences (BNLMS).
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12) The synthetic procedure was provided in the Supporting
4
(
(
1
5
(
2
(
Information. Very recently, Klussmann and co-workers reported an
acid catalyzed method for the synthesis of γ-carbonyl tert-
butylperoxides: Schweitzer-Chaput, B.; Demaerel, J.; Engler, H.;
Klussmann, M. Angew. Chem., Int. Ed. 2014, 53, 8737.
(
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S.; Lanza, G.; Zecchi, G. Adv. Synth. Catal. 2012, 354, 159. (b) Hashmi,
A. S. K.; Yang, W.; Rominger, F. Adv. Synth. Catal. 2012, 354, 1273.
(
c) Zhuo, C.-X.; Wu, Q.-F.; Zhao, Q.; Xu, Q.-L.; You, S.-L. J. Am.
Chem. Soc. 2013, 135, 8169.
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14) The possible structures of 3l′ and 3m′:
(
15) Alternatively, the initial oxycarbenium derived from Hoch
rearrangement might be trapped reversibly by the indole nitrogen to
D
dx.doi.org/10.1021/ol5025053 | Org. Lett. XXXX, XXX, XXX−XXX