Total synthesis of (-)-decarestrictine D through a stereoselective intramolecular Nozaki-Hiyama-Kishi reaction

Article abstract of DOI:10.1016/S0040-4039(98)00837-5

A concise total synthesis of (-)-decarestrictine D (1) from 1,3- propanediol and polyhydroxybutyrate (PHB) is described. The approach involves the stereoselective intramolecular Nozaki-Hiyama-Kishi coupling to construct the decanolide ring and to set the proper configuration at C-7.