Large-scale synthesis of β-L-fucopyranosyl phosphate and the preparation of GDP-β-L-fucose

Article abstract of DOI:10.1016/0008-6215(93)80022-7

A practical 15-mmol large-scale synthesis of β-L-fucopyranosyl dicyclohexylammonium phosphate from L-fucose in 63percent overall yield was developed.The synthesis took advantage of a neighboring Bz-2 group participating in a Koenigs-Knorr like glycosylati